Attentional Mechanisms in SCD

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT06002477
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Subjective Cognitive Decline

Eligibility Criteria

Sex
ALL
Age
55 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Mecamylamine Challenge — DRUG
    Mecamylamine 20 mg oral pill administered once
  • Placebo Comparator Challenge — OTHER
    Matching placebo oral pill administered once

Study Details

This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by compensatory attention network activity, supported by enhanced cholinergic function. The investigators anticipate that SCD will be associated with greater compensatory attention network activity and that disrupting this compensatory process through anticholinergic challenge will result in a greater negative effect on attentional performance (Attention Network Test, ANT) and attention network functioning (EEG) in older adults with greater subjective cognitive concern.

Key Dates

Start date
Jun 6, 2025
Status verified
Jun 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Anticholinergic Challenge
    All participants will receive oral mecamylamine for 1 day
  • Placebo Comparator: Placebo Challenge
    All participants will receive oral placebo for 1 day

Primary Outcome Measure

Peak P1 amplitude for Orienting [ Time Frame: After administration of second drug challenge, approximately 72 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37212-

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Vanderbilt University Medical Center· Nashville, TN

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