PRT for Adolescents With High Functioning Autism

Part of paid clinical trials in Palo Alto, California.

Sponsor
Stanford University
Study ID
NCT05987761
Status
Recruiting
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Conditions

  • Autism
  • Autism Spectrum Disorder High-Functioning
  • Behavior, Child
  • Behavior, Social
  • Child Development
  • Developmental Disability

Eligibility Criteria

Sex
ALL
Age
11 Years - 14 Years
Healthy Volunteers
Not accepted

Interventions

  • PRT for Adolescents — BEHAVIORAL
    Clinician-led 70-minute PRT sessions targeting social skills once per week at Stanford.

Study Details

The purpose of this study is to identify improvement in behavioral and social function and changes in the brain following Pivotal Response Treatment (PRT) for Adolescents in highly verbal adolescents with autism spectrum disorder (ASD).

Key Dates

Start date
Sep 1, 2023
Status verified
Mar 2024
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
76 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: PRT Treatment Group
    After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-intervention MRI brain scan and behavioral assessments and will then be assigned randomly to one of two arms of intervention for 9 weeks. Participants in the PRT Treatment Group will complete an 9-week intervention, PRT for Adolescents, to improve the adolescent's social skills. Following the completion of the 9-week intervention, participants will be asked to complete a second MRI brain imaging session, followed by post-measure appointments in order to assess immediate effects of the intervention.
  • Experimental: Delayed Treatment Group
    After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-intervention MRI brain scan and behavioral assessments and will then be assigned randomly to one of two arms of intervention for 9 weeks. After 9-weeks without any intervention, participants in the Delayed Treatment Group will be asked to complete a second MRI brain imaging session, followed by post-measure appointments, and will then receive the PRT intervention at the end of the study.

Primary Outcome Measure

(Target) Change from baseline (Pre-training) in brain connectivity between superior temporal sulcus (STS) and the nucleus accumbens (NAc) [ Time Frame: Pre-treatment baseline, and between 11 to 13 weeks post-baseline ]

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford Research ParkPalo AltoCalifornia94304
Study Team
[email protected]
650-485-3149
Lynn Koegel, Ph.D.
[email protected]
Daniel A Abrams, Ph.D. (PRINCIPAL_INVESTIGATOR)

Find similar trials in Palo Alto, CA

By condition
Autism spectrum disorder
By specialty
Pediatrics
By research site
Stanford Research Park· Palo Alto, CA

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