Brain Slice Explants to Predict Drug Response in Brain Tumors

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
UNC Lineberger Comprehensive Cancer Center
Study ID
NCT05978557
Status
Recruiting
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Conditions

  • Central Nervous System Tumor

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Biospecimen collection — OTHER
    Biospecimen will be collected during surgery.

Study Details

This biospecimen collection study will evaluate the feasibility of engrafting and testing resected Central nervous system (CNS) tumors tumor tissue ex vivo to estimate drug response, in pediatric and adult subjects. CNS tumors display remarkable heterogeneity and unfortunately there are no reliable precision oncology platforms that can identify the most effective therapy for each patient. Recent work has demonstrated the success of functional precision oncology platforms using patient-derived explant (PDE) at predicting drug response in various cancers. Since PDEs maintain important aspects of tumor heterogeneity they may prove effective as functional models for CNS tumors. The purpose of this study is to explore the feasibility of using a novel PDE platform to generate drug sensitivity scores from patients with central nervous system tumors in Pediatric and adult subjects having low- or high-grade CNS tumors resected. The secondary objective is to estimate the proportion of successfully scaled PDEs generated per given tumor size.

Key Dates

Start date
Jul 27, 2023
Status verified
Aug 2025
Primary completion
Mar 1, 2028
Completion
Mar 1, 2028

Study Design

Enrollment
50 participants (estimated)

Primary Outcome Measure

Proportion of specimens yielding scores [ Time Frame: Up to 28 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UNC Lineberger Comprehensive Cancer CenterChapel HillNorth Carolina27516
Andrew B Satterlee, PhD
[email protected]
Devin McCarthy
[email protected]

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