Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor
University of Cincinnati
Study ID
NCT05973799
Status
Recruiting
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Conditions

  • Hypoglycemia
  • Type1diabetes

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Fasting — OTHER
    Subjects remain fasted prior to insulin-induced hypoglycemia.
  • Feeding — OTHER
    Subjects eat a normal breakfast and lunch prior to insulin-induced hypoglycemia.

Study Details

Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D). In a previous study, it was observed in people without diabetes that fasting can be detrimental to the hormonal and hepatic responses to insulin-induced hypoglycemia. In the experiments described herein, the impact fasting has on hypoglycemic counterregulation in people with T1D will be determined.

Key Dates

Start date
Oct 10, 2019
Status verified
Aug 2024
Primary completion
Dec 31, 2024
Completion
Dec 31, 2024

Study Design

Enrollment
10 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Fasting
    Subjects will remain fasted prior to insulin-induced hypoglycemia.
  • Experimental: Feeding
    Subjects will eat a normal breakfast and lunch prior to insulin-induced hypoglycemia.

Primary Outcome Measure

Glucagon [ Time Frame: During procedure, up to 2.5 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of CincinnatiCincinnatiOhio45267-0547
Jason Winnick, PhD
[email protected]
513-558-4437

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By research site
University of Cincinnati· Cincinnati, OH

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