Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT05961800
Status
Recruiting
Apply to this trial

Conditions

  • Analgesia
  • Facet Joint Pain
  • Pain, Chronic
  • Pain, Procedural

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cutaneous Probe — BEHAVIORAL
    A computer-controlled probe delivers temperatures to the skin to measure pain, offset analgesia and onset hyperalgesia.
  • Quantitative Sensory Testing — BEHAVIORAL
    Standard methods involving pinprick, pressure, heat, and cold applied to the skin are used to measure sensation and pain
  • Computer Tasks — BEHAVIORAL
    Quantitative Sensory Testing (QST) and computer tasks are used to measure changes in pain intensity.

Study Details

This study examines the relationship between central nervous system (CNS) mechanisms of pain inhibition and the pain relief that occurs following a lumbar medial branch block (MBB).

Key Dates

Start date
Jul 5, 2023
Status verified
Jun 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Quantitative Sensory Testing
    Participants with chronic low back pain and a scheduled lumbar medial branch block undergo quantitative sensory testing.

Primary Outcome Measure

Offset analgesia and onset hyperalgesia [ Time Frame: during this portion of the study visit (30 minutes) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UPMC St. MargaretPittsburghPennsylvania15215
Maya L Maurer, BS
[email protected]
412-665-8052
Benedict J Alter, MD, PhD
[email protected]
412-677-0575
Benedict J Alter, MD, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
UPMC St. Margaret· Pittsburgh, PA

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