Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT05948930
Status
Recruiting
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Conditions

  • Mild Cognitive Impairment

Eligibility Criteria

Sex
ALL
Age
50 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Progressive aerobic exercise — BEHAVIORAL
    Progressive aerobic exercise
  • Adaptive cognitive training — BEHAVIORAL
    Adaptive cognitive training
  • Combined — BEHAVIORAL
    Combine adaptive cognitive and progressive aerobic exercise training

Study Details

The prevalence of dementia will double in the next three decades in the U.S.; effective treatment or prevention for dementia is urgently needed. The current exploratory project aims to evaluate and understand how the brain and cognition may improve after a 12-week intervention that combines brain training and aerobic exercise training to improve brain function, both in those with mild cognitive impairment (some with possible prodromal Alzheimer's disease) and with healthy aging. Findings from this pilot project will guide and refine the development of a future larger clinical trial that aligns with the goals of the National Alzheimer's Plan of Action (NAPA), especially regarding "Prevent and Effectively Treat Alzheimer's Disease (AD) by 2025.

Key Dates

Start date
Jan 8, 2024
Status verified
May 2026
Primary completion
Dec 16, 2026
Completion
Aug 7, 2027

Study Design

Enrollment
90 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Aerobic Exercise
    Progressive aerobic exercise 3x/week for 12 weeks.
  • Experimental: Cognitive Training
    Adaptive cognitive training on Cogmed 5x/week for a total of 25 sessions in 5-8 weeks.
  • Experimental: Combined Cognitive and Aerobic Exercise
    Combined progressive aerobic exercise 3x/week for 12 weeks and adaptive cognitive training on Cogmed 5x/week for a total of 25 sessions in 5-8 weeks simultaneously.

Primary Outcome Measure

Changes in Brain structure measures [ Time Frame: At baseline and at 4 weeks after the corresponding training program. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Maryland BaltimoreBaltimoreMaryland21201
Huajun Liang, MBBS, PhD
[email protected]
410-706-1031

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By research site
University of Maryland Baltimore· Baltimore, MD

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