A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT05931367
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Retatrutide — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The main purpose of this study is to evaluate the safety and efficacy of retatrutide once-weekly in participants who have obesity or are overweight and have osteoarthritis (OA) of the knee. The study will lasts about 77 weeks.

Key Dates

Start date
Aug 1, 2023
Status verified
Jan 2026
Primary completion
Nov 14, 2025
Completion
Nov 14, 2025

Study Design

Enrollment
445 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide Dose 1
    Participants will receive retatrutide subcutaneously (SC).
  • Experimental: Retatrutide Dose 2
    Participants will receive retatrutide SC.
  • Placebo Comparator: Placebo
    Participants will receive placebo.

Primary Outcome Measure

Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score [ Time Frame: Baseline, Week 68 ]

Locations (13)

FacilityCityStateZIPSite coordinators
Arizona Research CenterPhoenixArizona85053-
Artemis Institute for Clinical ResearchSan DiegoCalifornia92103-
Chase Medical Research, LLCWaterburyConnecticut06708-
Suncoast Research GroupMiamiFlorida33135-
North Georgia Clinical ResearchWoodstockGeorgia30189-
Elite Clinical TrialsBlackfootIdaho83221-
Northwestern UniversityChicagoIllinois60611-
MedVadis Research CorporationWalthamMassachusetts02451-
Great Lakes Research Group, Inc.Bay CityMichigan48706-
Clinvest Research LLCSpringfieldMissouri65807-
Mercy Family ClinicDallasTexas75211-
Clinical Trials of Texas, Inc.San AntonioTexas78229-
Northwest Clinical Research CenterBellevueWashington98007-

Related coverage on Hipa.ai

Find similar trials in Phoenix, AZ

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Arizona Research Center· Phoenix, AZArtemis Institute for Clinical Research· San Diego, CAChase Medical Research, LLC· Waterbury, CTSuncoast Research Group· Miami, FLNorth Georgia Clinical Research· Woodstock, GAElite Clinical Trials· Blackfoot, ID

Related Studies