Impact of Yo-Yo Sleep on Cardiometabolic Health

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT05880758
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 49 Years
Healthy Volunteers
Accepted

Interventions

  • Intermittent Short Sleep (ISS) — BEHAVIORAL
    Restricted sleep duration of \<5.5 h/night for 5 nights (SR) followed by 2 nights of 9.5 hours of time in bed (TIB) (recover sleep) each week.
  • Social Jetlag (SJL) — BEHAVIORAL
    2-hour delayed sleep timing.
  • Sustained Adequate Sleep (SAS) — BEHAVIORAL
    Goal of ≥7 hours of sleep/night with 8 hours of time in bed (TIB).

Study Details

The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determine if maintaining a constant midpoint of sleep while undergoing intermittent short sleep, leads to better outcomes than intermittent short sleep with a 2-hour delay in sleep midpoint. The aims of this research will be tested in the context of a 3-group, parallel-arm, outpatient intervention of 4 weeks in duration, in young-to-middle-aged adults (aged 18-49 years).

Key Dates

Start date
Sep 22, 2023
Status verified
May 2026
Primary completion
Dec 31, 2027
Completion
Jun 30, 2028

Study Design

Enrollment
72 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Stable Adequate Sleep (SAS)
    Participants will go to bed and wake up at the same time every night, maintaining adequate sleep duration.
  • Experimental: ISS_Alone
    Intermittent short sleep (ISS) 5 nights of 5.5 hours time in bed 2 nights of 9.5 hours time in bed with advanced bedtimes and delayed wake times
  • Experimental: ISS_SJL
    Intermittent short sleep with short jetlag (SJL) 5 nights of 5.5 hours time in bed 2 nights of 9.5 hours time in bed with constant bedtimes and delayed wake times

Primary Outcome Measure

Fasting Plasma Glucose [ Time Frame: Up to 4 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10032
Marie-Pierre St-Onge, PhD
[email protected]
212-305-9549
Marie-Pierre St-Onge, PhD (PRINCIPAL_INVESTIGATOR)
Sanja Jelic, MD (SUB_INVESTIGATOR)

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