Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

Part of paid clinical trials in Orlando, Florida.

Sponsor
AdventHealth
Study ID
NCT05877885
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Targeted Cognitive Training Intervention — BEHAVIORAL
    In this intervention, participants will complete 25-30 minutes of cognitive training per day, 5 days/week (but up to 7 days/week) for 4 weeks. The training protocol will be delivered via the Posit Science Platform, and includes tasks that emphasize training of sustained attention, salience detection, and dimensions of cognitive control. During the 4 week intervention, participants will have weekly 10-20 minute visits with a Care Manager to provide clinical monitoring of symptoms and structured support to participants.
  • General Cognitive Training Intervention — BEHAVIORAL
    In this intervention, participants will complete 25-30 minutes of cognitive activities per day, 5 days/week (but up to 7 days/week) for 4 weeks. The training protocol will be delivered via the Posit Science Platform. The intervention protocol will include computerized cognitive activities designed to provide general cognitive stimulation. During the 4 week intervention, participants will have weekly 10-20 minute visits with a Care Manager to provide clinical monitoring of symptoms and structured support to participants.

Study Details

The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy and related cognitive and behavioral deficits. The investigators hypothesize that 4 weeks of a customized digital cognitive training program will lead to changes in brain connectivity, apathy severity, and cognitive control performance.

Key Dates

Start date
Sep 19, 2025
Status verified
Oct 2025
Primary completion
Nov 1, 2028
Completion
Dec 1, 2028

Study Design

Enrollment
84 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Targeted Cognitive Training Intervention
  • Active Comparator: General Cognitive Training Intervention

Primary Outcome Measure

Change in Resting State Functional Connectivity among the Salience, Executive Control, and Reward Networks [ Time Frame: Baseline and Post-treatment (Week 4) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
AdventHealth Neuroscience InstituteOrlandoFlorida32804
Lauren E Oberlin, PhD
[email protected]
(860) 690-8441
Lauren Oberlin, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Orlando, FL

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
AdventHealth Neuroscience Institute· Orlando, FL

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