Exercise Response in Humans With Obesity

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT05857150
Status
Recruiting
Apply to this trial

Conditions

  • Obese

Eligibility Criteria

Sex
ALL
Age
20 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Treadmill Test — DIAGNOSTIC_TEST
    Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).
  • Strength Test — DIAGNOSTIC_TEST
    Measure the strength of leg muscles by kicking against a machine with resistance.
  • Dual-Energy X-Ray Absorptiometry — DIAGNOSTIC_TEST
    Body composition measurement.
  • Muscle Biopsy — PROCEDURE
    Obtain a small piece of muscles from the upper part of the legs
  • Fat Biopsy — PROCEDURE
    Fat sample taken from abdomen
  • Resting Energy Expenditure — DIAGNOSTIC_TEST
    Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.
  • Magnetic resonance imaging — DIAGNOSTIC_TEST
    MRI on upper leg to look at fat and muscle

Study Details

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

Key Dates

Start date
Sep 22, 2023
Status verified
Aug 2025
Primary completion
Jul 31, 2029
Completion
Jul 31, 2029

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Lean Group
    Participants with body mass index 20-25 kg/m\^2 will complete an outpatient study visit (body composition, blood draw, treadmill test, strength test) and an inpatient visit (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).
  • Arm: Obese Group
    Participants with body mass index 30-45 kg/m\^2 will complete an outpatient study visit (body composition, blood draw, treadmill test, strength test) and an inpatient visit (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).

Primary Outcome Measure

Change in muscle protein synthesis [ Time Frame: Baseline, post-exercise approximately 8 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in RochesterRochesterMinnesota55905
Rachel Passehl
[email protected]
507-255-8112

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Mayo Clinic in Rochester· Rochester, MN

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