Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

Part of paid clinical trials in Maywood, Illinois.

Sponsor
Loyola University
Study ID
NCT05824832
Phase
PHASE4
Status
Recruiting
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Conditions

  • Pain, Postoperative

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Interscalene block with the addition of buprenorphine, clonidine, dexamethasone — DRUG
    Addition of the adjuvant buprenorphine, dexamethasone, and clonidine in the nerve block performed prior to shoulder arthroscopy surgery
  • Interscalene block with buprenorphine alone — DRUG
    Addition of the adjuvant buprenorphine alone the in nerve block performed prior to shoulder arthroscopy surgery

Study Details

The goal of this clinical trial is to learn if there is a difference in morphine requirements in patients after upper extremity surgeries including shoulder arthroscopy. The main question it aims to answer is whether there is a difference between Interscalene brachial plexus blocks with the addition of buprenorphine, dexamethasone, and clonidine and the same block without the adjuvant.

Key Dates

Start date
Feb 28, 2023
Status verified
Mar 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Interscalene block with the addition of buprenorphine, clonidine, dexamethasone
    Interscalene brachial plexus blocks (ISB) is performed with a 22g x 50 mm PAJUNK SonoPlexⓇ II Facet S echogenic needle. Once adequate needle visualization is achieved within the correct anatomic position and plane, 30mL of 0.5% bupivacaine with 100 mcg clonidine, 0.3 mg buprenorphine, and 4 mg dexamethasone will be injected.
  • Active Comparator: Interscalene block with buprenorphine alone
    Interscalene brachial plexus blocks (ISB) is performed with a 22g x 50 mm PAJUNK SonoPlexⓇ II Facet S echogenic needle. Once adequate needle visualization is achieved within the correct anatomic position and plane 30mL of 0.5% bupivacaine will be injected.

Primary Outcome Measure

Morphine requirement post surgery [ Time Frame: 24 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Loyola University ChicagoMaywoodIllinois60153
Susan Fargo
[email protected]
708-216-8046
Audrice Francois, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Loyola University Chicago· Maywood, IL

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