Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT05795634
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Trier Social Stress Test — BEHAVIORAL
    Acute psychosocial stress procedure; 5 minutes of public speaking and 5 minutes of mental arithmetic

Study Details

The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment. The main question\[s\] it aims to answer are: * Does the hormone response to acute stress predict the degree of cognitive impairment following acute stress? * Do genes associated with the risk for Alzheimer's disease influence the relationship between stress hormone response to stress and cognitive impairment following stress? * Do cognitive impairment following acute stress and genes associated with the risk for Alzheimer's disease predict cognitive decline and change in biomarkers for Alzheimer's disease 2 years later? Participants will have 3 in-person study visits. The first 2 will occur at baseline and the 3rd visit will occur 2 years later. During the visits, participants will provide blood and saliva samples, undergo a 10-minute social stress procedure, complete questionnaires, and take tests of memory and other thinking skills. Someone who knows the participant (a "study partner") will be asked questions about the participant's daily functioning at the first and 3rd study visits.

Key Dates

Start date
Mar 1, 2023
Status verified
Jan 2026
Primary completion
Mar 1, 2028
Completion
Mar 1, 2029

Study Design

Enrollment
240 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Other: Trier Social Stress Test
    All participants in the study will get undergo the same stress procedure

Primary Outcome Measure

Change in mean memory test composite score [ Time Frame: Baseline and Visit 2 (up to 1 month) and Baseline to Visit 3 (up to 2 years) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins School of MedicineBaltimoreMaryland21224
Nick Bienko, MA
[email protected]
410-550-2036

Find similar trials in Baltimore, MD

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Johns Hopkins School of Medicine· Baltimore, MD

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