Cannabis and Opioid Use Disorder

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
University of Kentucky
Study ID
NCT05729932
Phase
PHASE1
Status
Recruiting
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Conditions

  • Opioid Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Inhaled vaporized cannabis — DRUG
    Double-blind cannabis and placebo doses, administered through vaporizer
  • Intransal opioid — DRUG
    Double-blind opioid and placebo doses, administered intranasal route

Study Details

This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related outcomes.

Key Dates

Start date
Sep 10, 2024
Status verified
Dec 2025
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
15 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Intranasal Opioid Agonist
    Participants will receive non-therapeutic, experimental doses of an opioid agonist or placebo. Active opioid agonist/placebo will be administered once per session and will be administered intransally (snorting).
  • Experimental: Vaporized cannabis
    Participants will receive non-therapeutic, experimental doses of active or placebo vaporized cannabis. Active cannabis/placebo will be administered once per session and will be administered via a vaporizer.

Primary Outcome Measure

Change from Baseline - Opioid Withdrawal Severity - Visual Analog Scale (VAS) [ Time Frame: Change from baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center on Drug and Alcohol ResearchLexingtonKentucky40508
Paul Nuzzo, MA
[email protected]
859-323-0002

Find similar trials in Lexington, KY

By research site
Center on Drug and Alcohol Research· Lexington, KY

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