Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC

Part of paid clinical trials in Houston, Texas.

Sponsor
M.D. Anderson Cancer Center
Study ID
NCT05709782
Phase
PHASE2
Status
Recruiting
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Conditions

  • Spinal Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Spine Radiosurgery — PROCEDURE
    scan
  • Magnetic Resonance imaging — DEVICE
    scan
  • MR-LINAC — RADIATION
    scan

Study Details

To learn whether giving spinal stereotactic radiosurgery (SRSS) that uses a more advanced imaging scan method called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) during treatment will lead to improved responses to treatment and better quality of life. SRSS is radiation therapy given to the area around your spine.

Key Dates

Start date
May 9, 2023
Status verified
Jan 2026
Primary completion
Jan 31, 2026
Completion
Jan 31, 2026

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Group 1 (Therapeutic Cohort)
    Participants in Group 1 will receive spine radiosurgery on the MR LINAC machine, along with imaging scans using the same machine.
  • Experimental: Group 2 (Imaging-only Cohort)
    Participants in Group 2 will receive spine radiosurgery using a standard radiation therapy machine and have the opportunity to get imaging on the MR LINAC.

Primary Outcome Measure

M. D. Anderson Symptom Inventory - Spine Tumor (MDASI-SP) questionnaires [ Time Frame: through study completion; an average of 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
M D Anderson Cancer CenterHoustonTexas77030
Debra Yeboa, MD
[email protected]
713-563-2415
Debra N. Yeboa, MD (PRINCIPAL_INVESTIGATOR)

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By research site
M D Anderson Cancer Center· Houston, TX

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