Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

Part of paid clinical trials in Los Angeles, California.

Sponsor
Children's Hospital Los Angeles
Study ID
NCT05685368
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Depression, Anxiety
  • Quality of Life
  • Race-related Stress
  • Stress Reaction

Eligibility Criteria

Sex
ALL
Age
14 Years - 21 Years
Healthy Volunteers
Not accepted

Interventions

  • ACT for SCD — BEHAVIORAL
    Phase I Using a convenience sample, this study examines the feasibility and acceptability of a proposed 6-session ACT group intervention for Black youth with sickle cell disease (SCD), who experience compounded stress due to chronic illness and systemic inequities. A up to 11 youth and up to 11 parents/legal guardians will be enrolled in an ACT group offered via the Division of Adolescent and Young Adult Medicine. Participants will complete assessments at pre-, and post-intervention, and at a 3-month follow-up. Up to 5 of 11 parents/legal guardians and 5 of 11 youth (not required to be dyadic) will also be a part of the studies community advisory board (CAB) to ensure the intervention is culturally and developmentally responsive and grounded in community perspectives. Phase II Over the next 3 years this study will use a community-based participatory action research approach, extending and integrating feedback data collected in Phase I, to conduct a crossover waitlist-control trial.

Study Details

The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study will consist of a small, purposeful, non-randomized sample (N = 30) of clients enrolled into a 10-session Acceptance and Commitment Therapy group. The group will be offered as part of regular clinical care at the Division of Adolescent and Young Adult Medicine. Three consecutive groups will be run with approximately 8-10 participants in each group over the next year.

Key Dates

Start date
Apr 1, 2025
Status verified
Apr 2026
Primary completion
Jun 30, 2029
Completion
Jun 30, 2029

Study Design

Enrollment
66 participants (estimated)
Allocation
NA
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Acceptance Commitment Therapy
    This study will use a 10-session ACT protocol to support Black adolescents and young adults in coping with race related stress.
  • No Intervention: Control Group
    Waitlist control group that will receive the intervention 3-4 months after the intervention group concludes.

Primary Outcome Measure

Total Score on Index of Race-Related Stress (IRRS)-Brief Version [ Time Frame: 12 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Children's Hospital Los AngelesLos AngelesCalifornia90027
Xzania W Lee, Ph.D.
[email protected]
323-361-4768

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By research site
Children's Hospital Los Angeles· Los Angeles, CA

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