Change in MAPSE During Treatment of Sepsis

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT05634733
Status
Recruiting
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Conditions

  • Sepsis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Treatment of Sepsis — OTHER
    Patients will have standard care of sepsis

Study Details

Patients with bloodstream infections (sepsis) have been found in prior studies to have infection-related heart dysfunction, even if they did not have preexisting heart problems. Factors related to the infection may cause the heart to not pump as well as it should, causing critical illness in the form of low blood pressure (shock) and heart failure. Ultrasound is frequently used in the emergency department to evaluate why a patient might have low blood pressure. Part of that evaluation may include obtaining ultrasound images and making measurements about how well or poorly the heart is pumping. The investigators will evaluate a certain measurement that relates to cardiac function, determine how it changes in patients before and after they are treated for septic shock. This will involve placing an ultrasound probe on the patient's chest, measuring the upward and downward movement of the mitral valve, the mitral annulus systolic plane excursion (MAPSE), and comparing the measurements before and after treatment is started. The investigators are attempting to determine if this measurement improves before and after treatment.

Key Dates

Start date
Apr 1, 2023
Status verified
Jun 2025
Primary completion
Apr 1, 2030
Completion
Dec 1, 2030

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Patients with Sepsis
    These are patients who present to the emergency department with sepsis. They will have a MAPSE at the time of enrollment and then after initial treatment.

Primary Outcome Measure

Change in MAPSE measurement [ Time Frame: 1 hour after treatment initiation ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Maryland Medical CenterBaltimoreMaryland21201
Alexis Salerno, MD

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By research site
University of Maryland Medical Center· Baltimore, MD

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