High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans

Part of paid clinical trials in Kansas City, Missouri.

Sponsor
VA Office of Research and Development
Study ID
NCT05625204
Status
Recruiting
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Conditions

  • Frailty

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Center based attention (stretching only) control — BEHAVIORAL
    Center based attention (stretching only) control
  • Center based HIIT — BEHAVIORAL
    Center based HIIT
  • Home based HIIT — BEHAVIORAL
    Home based HIIT

Study Details

Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, defined as the capacity to recover from disruptions to homeostasis, is critical to successful aging because it precedes frailty and enhances adults' ability to maintain optimal health and function well into older age. Evidence- based therapies to help older adults enhance resilience are limited and the biological underpinnings contributing to improved resilience have not yet been fully characterized. To address this important need, the investigators will conduct a clinical trial to examine the benefits of center- and home-based high intensity interval training (HIIT) on functional capacity, frailty, and resilience, and also to identify novel biomarkers of resilience in older Veterans.

Key Dates

Start date
Jan 29, 2024
Status verified
Dec 2025
Primary completion
Jul 1, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Center based attention control
    Center based attention control
  • Experimental: Center based HIIT
    Center based HIIT
  • Experimental: Home based HIIT
    Home based HIIT

Primary Outcome Measure

Sub-maximal oxygen uptake test (VO2max) [ Time Frame: Change from baseline to endpoint at 12 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Kansas City VA Medical Center, Kansas City, MOKansas CityMissouri64128-2226
Ramratan R Sharma, PhD MHSA
[email protected]
(816) 922-2757
Bruce R. Troen, MD (PRINCIPAL_INVESTIGATOR)
Kansas City VA Medical Center, Kansas City, MOKansas CityMissouri64128
Bruce R Troen, MD
[email protected]
Kenneth L Seldeen, PhD
[email protected]

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By research site
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