Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor Microenvironment

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT05600933
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Background: Many advances have been made in cancer treatments, but more research is needed. Comparing samples of cancerous tissue to samples of normal, noncancerous tissues may help find differences between them. These differences may help researchers find new ways to treat cancer. Objective: To collect tissues and blood samples from people with known or suspected cancer. The samples will be used to help identify new targets for cancer treatments. Eligibility: People aged 18 years and older with a known or suspected cancer that requires surgery or biopsy. Design: Participants will be screened. They will answer questions about their health. They can do this on the phone or in person. Researchers will collect information from participants medical records. Data may include information about any prior or current cancers. Data about other medical conditions may also be collected. Participants will have blood drawn. Some of the blood will be tested for HIV and hepatitis B and C. Some of the blood will be used for genetic research. Participants will have tissue samples collected during surgeries or biopsies. These are procedures the participants would have had as part of their standard care. No new procedures will be done just for this study. Researchers may also seek out samples from prior procedures the participant had done. Participants will remain in the study for 6 months. They may have blood drawn again. Researchers may also collect tissue samples from any procedures performed during that time.

Key Dates

Start date
May 15, 2023
Status verified
May 2026
Primary completion
Jun 15, 2033
Completion
Jun 15, 2033

Study Design

Enrollment
1,200 participants (estimated)

Arms

  • Arm: 1 - premalignant, primary or metastatic solid tumor
    Participants \>= 18 with a suspected or confirmed solid tumor malignancy that requires surgery or biopsy.
  • Arm: 2 - known or suspected hematologic malignancy
    Participants \>= 18 who have a known or suspected hematologic malignancy that requires surgery or biopsy.

Primary Outcome Measure

To collect biologic samples from participants undergoing diagnostic or therapeutic interventions for premalignant, primary or metastatic solid tumors and hematologic malignancies [ Time Frame: At time of surgery or biopsy ]

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892-

Find similar trials in Bethesda, MD

By condition
Liver cancerLung cancerMelanomaPancreatic cancer
By specialty
OncologyGI oncologyHepatologyLung oncologyLung diseaseSkin cancerDermatology
By research site
National Institutes of Health Clinical Center· Bethesda, MD

Related Studies