Exercise to Improve Brain Health in Older African Americans

Part of paid clinical trials in Newark, New Jersey.

Sponsor
Rutgers, The State University of New Jersey
Study ID
NCT05597124
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Cardio-Dance Fitness — BEHAVIORAL
    This is an aerobic cardio-dance fitness exercise class in a social context with aerobic intensity assessed by heart rate monitoring throughout the class. Participants will meet three times a week for approximately 60 minutes per session, over 24 weeks (approximately 6 months).
  • Strength, Flexibility & Balance — BEHAVIORAL
    This intervention will serve as a stringent, structurally equivalent, active comparator to the CDF intervention, identical in duration, frequency, and social contact except for the content of this non-aerobic intervention. SFB will involve non-aerobic activity with strength, flexibility, and balance training.

Study Details

The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question\[s\] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Balance (SFB) intervention on a cognitive marker of Alzheimer's risk, generalization? * What is the effect of the CDF vs. SFB intervention on a fMRI biomarker of Alzheimer's, neural flexibility, and do improvements in neural flexibility mediate improvements in generalization? * Do ABCA7 genotypic variations moderate the efficacy of the CDF vs. SFB intervention for reducing Alzheimer's risk? Participants will undergo-- at baseline and post-test-- health assessments, cognitive tests, and structural and functional magnetic resonance imaging (fMRI), and a blood-draw to assess Alzheimer's risk biomarker levels.

Key Dates

Start date
Apr 20, 2023
Status verified
Feb 2026
Primary completion
Jun 1, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
280 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Cardio-Dance Fitness
    This is the experimental group. Participants will meet three times a week for dance classes for approximately 60 minutes per session, over 24 weeks (approximately 6 months).
  • Active Comparator: Strength, Flexibility & Balance
    This is the active control group. Participants will meet three times a week for strength, flexibility, and balance exercises for approximately 60 minutes per session, over 24 weeks (approximately 6 months).

Primary Outcome Measure

Generalization Performance on the Concurrent Discrimination and Transfer Task [ Time Frame: Changes from baseline to six months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Rutgers, The State University of New Jersey - Newark campusNewarkNew Jersey07102
Lisa Haber-Chalom
[email protected]
Mark A. Gluck, PhD (PRINCIPAL_INVESTIGATOR)
Bernadette A. Fausto, PhD (SUB_INVESTIGATOR)
Paul R. Duberstein, PhD (SUB_INVESTIGATOR)
Steven K. Malin, PhD (SUB_INVESTIGATOR)
William Hu, MD, PhD, FAAN (SUB_INVESTIGATOR)
Liangyuan Hu, PhD (SUB_INVESTIGATOR)

Find similar trials in Newark, NJ

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Rutgers, The State University of New Jersey - Newark campus· Newark, NJ

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