Application of the Modified Story Memory Technique (mSMT)© to Aging

Part of paid clinical trials in East Hanover, New Jersey.

Sponsor
Kessler Foundation
Study ID
NCT03370224
Status
Enrolling By Invitation

Conditions

  • Aging
  • Mild Cognitive Impairment

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Memory retraining exercises — BEHAVIORAL
    Memory retraining exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).
  • Placebo control memory exercises — BEHAVIORAL
    Placebo control memory exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).

Study Details

This study is a double-blind placebo-controlled randomized clinical trial (RCT) to provide Class I evidence in support of or in refute of the efficacy of the modified Story Memory Technique (mSMT) in healthy aging (HA)and in persons with mild cognitive impairment (MCI). Outcomes will be measured through three mechanisms: (1) a traditional neuropsychological evaluation (NPE) (2) an assessment of global functioning (AGF) examining the impact of the treatment on daily activities, and (3) an optional functional magnetic resonance imaging (fMRI) scan.

Key Dates

Start date
Nov 1, 2017
Status verified
Aug 2025
Primary completion
Nov 1, 2026
Completion
Nov 1, 2026

Study Design

Enrollment
33 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Experimental Group
    The experimental group will receive memory retraining exercises administered on a laptop computer twice a week for 5 weeks (10 training sessions).
  • Placebo Comparator: Placebo
    The placebo group will receive placebo control memory exercises administered on a laptop computer twice a week for 5 weeks (10 training sessions).

Primary Outcome Measure

Change in scores on standardized neuropsychological tests of memory using the California Verbal Learning Test [ Time Frame: Scores will be assessed at five time-points: Baseline (week 1), immediately post-intervention (week 7) and 6, 12, 24 months, and 6 years post-intervention. ]

Locations (1)

FacilityCityStateZIPSite coordinators
Kessler FoundationEast HanoverNew Jersey07936-

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