Benefits of Nicotinamide Riboside Upon Cognition and Sleep

Part of paid clinical trials in Buffalo, New York.

Sponsor
State University of New York at Buffalo
Study ID
NCT05500170
Status
Recruiting
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Conditions

  • Cognitive Impairment
  • Sleep Quality

Eligibility Criteria

Sex
ALL
Age
65 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Nicotinamide riboside — DIETARY_SUPPLEMENT
    Nicotinamide riboside (NR) is a form of vitamin B3, which is found in fruits, vegetables, meat, and milk. NR is converted into nicotinamide adenosine dinucleotide NAD+. Low NAD+ levels have been linked to Alzheimer's disease and sleep disturbances.
  • Placebo — DIETARY_SUPPLEMENT
    The placebo pill will contain micro cellulose powder.

Study Details

Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.

Key Dates

Start date
Apr 4, 2023
Status verified
Aug 2025
Primary completion
Aug 30, 2027
Completion
Aug 30, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Intervention
    Participants in the intervention group will receive 500mg of NR twice daily
  • Placebo Comparator: Placebo
    Participants in the intervention group will receive 500mg of sham placebo twice daily

Primary Outcome Measure

Sleep Quality Assessment [ Time Frame: Change from baseline to endpoint at 12 weeks ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Buffalo Veteran Affairs Medical CenterBuffaloNew York14215
Carleara Weiss, PhD
State University of New York at BuffaloBuffaloNew York14203
Carleara Weiss, PhD, MS, RN
University at Buffalo State University of New YorkBuffaloNew York14203
Carleara Weiss, PhD, MS, RN
[email protected]
716-829-2006

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By research site
Buffalo Veteran Affairs Medical Center· Buffalo, NYState University of New York at Buffalo· Buffalo, NYUniversity at Buffalo State University of New York· Buffalo, NY

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