Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

Part of paid clinical trials in Orange, California.

Sponsor
University of California, Irvine
Study ID
NCT05497531
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ctDNA Blood Collection — DIAGNOSTIC_TEST
    Blood collection to be obtained from peripheral vein and cancer draining vein during biopsy

Study Details

This is a prospective pilot protocol investigating whether ctDNA detection be improved by sampling the cancer draining vein versus the standard practice of sampling from a peripheral vein in patients who are undergoing biopsies for hepatobiliary and pancreatic cancers.

Key Dates

Start date
Sep 7, 2022
Status verified
Feb 2026
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
15 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: ctDNA collection from draining and peripheral veins
    Patient with suspected primary hepatobiliary or pancreatic cancer undergoing a diagnostic work-up with a percutaneous or trans-jugular biopsy (standard of care) and will undergo a sampling of the cancer draining vein during their biopsy procedure with a collection of an additional 10mL of blood.

Primary Outcome Measure

Comparison of the amount of ctDNA in draining vein plasma sample to peripheral vein sample through ratio of mean allele frequency [ Time Frame: Up to 1 year ]

Central Contacts

  • Chao Family Comprehensive Cancer Center University of California, Irvine
    1-877-827-7883
    [email protected]
  • University of California Irvine Medical

Locations (1)

FacilityCityStateZIPSite coordinators
Chao Family Comprehensive Cancer Center, University of California, IrvineOrangeCalifornia92868
Nadine Abi-Jaoudeh, MD
[email protected]
877-827-8839

Find similar trials in Orange, CA

By condition
Liver cancerPancreatic cancer
By specialty
OncologyGI oncologyHepatology
By research site
Chao Family Comprehensive Cancer Center, University of California, Irvine· Orange, CA

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