A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma

Part of paid clinical trials in Duarte, California.

Sponsor
Janssen Research & Development, LLC
Study ID
NCT05421663
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Lymphoma, B-Cell
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, Non-Hodgkin

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Prizloncabtagene autoleucel (Prizlo-Cel) — BIOLOGICAL
    Prizlo-Cel, an autologous dual targeting chimeric antigen receptor (CAR) - T cell therapy targeting Cluster of differentiation (CD)20 and CD19.

Study Details

This is a Phase 1b/2, multicenter, open-label, study of prizloncabtagene autoleucel (prizlo-cel), an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL).

Key Dates

Start date
Aug 12, 2022
Status verified
Jun 2026
Primary completion
Dec 29, 2028
Completion
Jul 30, 2041

Study Design

Enrollment
439 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Prizlo-Cel
    Participants will receive intravenous (IV) infusion of autologous prizlo-cel.

Primary Outcome Measure

Phase 1b: Occurrence of Adverse Events (AEs) [Safety and Tolerability] [ Time Frame: Up to 2 Years post prizlo-cel infusion ]

Central Contacts

Locations (14)

FacilityCityStateZIPSite coordinators
City of HopeDuarteCalifornia91010-
Colorado Blood Cancer InstituteDenverColorado80218-
University of Iowa Hospital and ClinicsIowa CityIowa52242-
University of Kentucky Medical CenterLexingtonKentucky40536-
Rutgers Cancer Institute of New JerseyPiscatawayNew Jersey08854-
Levine Cancer InstituteCharlotteNorth Carolina28001-
University Hospitals Cleveland Medical CenterClevelandOhio44106-
University of Pittsburgh Medical CenterPittsburghPennsylvania15232-
Greco Hainesworth Tennessee Oncology Centers for ResearchNashvilleTennessee37203-
Sarah Cannon Research InstituteNashvilleTennessee37203-
St. David's South Austin Medical CenterAustinTexas78704-
MD Anderson Cancer CenterHoustonTexas77030-
Texas Transplant InstituteSan AntonioTexas78229-
Swedish Cancer InstituteSeattleWashington98104-

Find similar trials in Duarte, CA

By research site
City of Hope· Duarte, CAColorado Blood Cancer Institute· Denver, COUniversity of Iowa Hospital and Clinics· Iowa City, IAUniversity of Kentucky Medical Center· Lexington, KYRutgers Cancer Institute of New Jersey· Piscataway, NJLevine Cancer Institute· Charlotte, NC

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