Assessment of the Ocular Microbiome in Health and Disease

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT05414994
Status
Recruiting
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Conditions

  • Eye Diseases
  • Microbial Colonization
  • Ophthalmopathy

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Eye swab — OTHER
    This is a simple swab under the eyelids of both eyes

Study Details

The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment. We will conduct a prospective, observational cohort study, including a longitudinal analysis of the ocular microbiome in adults.

Key Dates

Start date
Sep 7, 2023
Status verified
Sep 2025
Primary completion
Sep 30, 2027
Completion
Dec 30, 2027

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Cohort A
    normal eyes with no ocular disease
  • Arm: Cohort B
    primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months
  • Arm: Cohort C
    non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)
  • Arm: Cohort D
    Dry AMD (age related macular degeneration)
  • Arm: Cohort E
    Wet AMD
  • Arm: Cohort F
    diabetic retinopathy, any stage

Primary Outcome Measure

Normal Ocular Microbiome [ Time Frame: 3 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37232
Sapna Gangaputra, M.D.

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