Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University
Study ID
NCT05412810
Status
Recruiting
Apply to this trial

Conditions

  • Hyperoxia
  • Mechanical Ventilation Complication

Eligibility Criteria

Sex
ALL
Age
18 Years - 110 Years
Healthy Volunteers
Not accepted

Interventions

  • oxygen — OTHER
    oxygen exposure of more than 50% for 1.5 hours

Study Details

The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics. The investigators will include patients with mechanical ventilation and have received FiO2=\>0.5 atleast 90 minutes and collected two sequential mini bronchoalveolar lavage on them 24 hours apart. Mass Spectrometry Lipid chromatography will be conducted and clinical data will be analyzed.

Key Dates

Start date
Mar 1, 2023
Status verified
Apr 2024
Primary completion
Mar 31, 2026
Completion
Sep 1, 2026

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Oxygen exposures
    mechanically ventilated patients with atleast 1.5 hours of FiO2 exposure of 50% or more

Primary Outcome Measure

Oxidized n6-PUFAs (Poly Unsaturated Fatty Acids) [ Time Frame: days 1, and 2 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Ohio State University Medical CenterColumbusOhio43210
Sonal Pannu
[email protected]
507-226-1636

Find similar trials in Columbus, OH

By research site
Ohio State University Medical Center· Columbus, OH

Related Studies