A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight

Conditions

• Obesity
• Overweight
• Type 2 Diabetes Mellitus

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Cagrilintide — DRUG
  Cagrilintide administered subcutaneously (s.c., under the skin) once-weekly
• Semaglutide — DRUG
  Semaglutide administered subcutaneously (s.c., under the skin) once-weekly
• Placebo cagrilintide — DRUG
  Placebo cagrilintide administered subcutaneously (s.c., under the skin) once-weekly
• Placebo semaglutide — DRUG
  Placebo semaglutide administered subcutaneously (s.c., under the skin) once-weekly

Study Details

This study will look at how well the new medicine CagriSema helps people living with excess body weight and type 2 diabetes losing weight. Participants will either get CagriSema or a dummy medicine. Which treatment they get is decided by chance. The study will last for about 1½ years. Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.

Key Dates

Start date

Feb 1, 2023

Status verified

Jan 2026

Primary completion

Jan 28, 2025

Completion

Feb 3, 2025

Study Design

Enrollment

1,200 participants (actual)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: CagriSema
  Cagrilintide + semaglutide once weekly
• Placebo Comparator: Placebo
  Placebo cagrilintide + semaglutide once weekly

Primary Outcome Measure

Relative change in body weight [ Time Frame: From baseline (week 0) to end of treatment (week 68) ]

Locations (49)

Find similar trials in Concord, CA

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