Valuation in Depressed Mood, Anhedonia, and Anxiety

Conditions

• Neurobehavioral Components of Reward and Loss Valuation

Eligibility Criteria

Sex

ALL

Age

25 Years - 50 Years

Healthy Volunteers

Not accepted

Interventions

• cognitive behavioral therapy — BEHAVIORAL
  cognitive behavioral therapy
• valuation with instruction — BEHAVIORAL
  repeat laboratory sessions of computerized learning game
• valuation without instruction — BEHAVIORAL
  repeat laboratory sessions of computerized learning game

Study Details

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Key Dates

Start date

Aug 1, 2021

Status verified

Sep 2025

Primary completion

Jul 31, 2026

Completion

Jul 31, 2026

Study Design

Enrollment

252 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Active Comparator: Cognitive behavioral therapy
  cognitive behavioral therapy for depression, anxiety, and/or anhedonia
• Active Comparator: Valuation with instruction
  repeat laboratory sessions of a reward/loss learning computer game with specific instructions
• Active Comparator: Valuation without instruction
  repeat laboratory sessions of a reward/loss learning computer game without specific instructions

Primary Outcome Measure

change in proportion correct on the 'N-arm bandit learning task' [ Time Frame: study entrance to study exit, an average of 12 weeks ]

Locations (1)

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