Exercise Training and Fat Metabolism in Postmenopausal Women

Part of paid clinical trials in Tallahassee, Florida.

Sponsor
Florida State University
Study ID
NCT05351476
Status
Recruiting
Apply to this trial

Conditions

  • Obesity
  • Postmenopausal Symptoms
  • Prediabetic State

Eligibility Criteria

Sex
FEMALE
Age
50 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Resistance Exercise — BEHAVIORAL
    200 Kcal worth of weightlifting, 3 times/week for 12 weeks
  • Endurance Exercise — BEHAVIORAL
    200 Kcal worth of treadmill walking, 3 times/week for 12 weeks

Study Details

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Key Dates

Start date
May 20, 2022
Status verified
Apr 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Resistance Exercise
    Participants do regular resistance exercise for 12 weeks.
  • Experimental: Endurance Exercise
    Participants do regular endurance exercise for 12 weeks.

Primary Outcome Measure

Change from baseline subcutaneous abdominal adipose tissue glycerol concentration at 12 weeks [ Time Frame: 12 weeks of resistance or endurance training ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Florida State UniversityTallahasseeFlorida32306
Michael J Ormsbee, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Tallahassee, FL

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Florida State University· Tallahassee, FL

Related Studies