Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University Hospital Freiburg
Study ID
NCT05337631
Status
Recruiting
Apply to this trial

Conditions

  • HNSCC
  • Hypopharynx Cancer
  • Larynx Cancer
  • Oral Cavity Cancer
  • Oropharynx Cancer

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and alternative chemotherapy fractionation (e.g., cisplatin weekly) may have altered this observation. The objective of this retrospective multinational multicenter study is to determine the oncological outcomes of elderly patients (≥65 years) with locally advanced HNSCCs undergoing definitive (chemo-)radiation and to investigate the influence of concomitant chemotherapy on overall survival and progression-free survival after adjusting for potential confounder variables such as age, performance status and comorbidity burden.

Key Dates

Start date
Jun 1, 2021
Status verified
Mar 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
1,500 participants (estimated)

Primary Outcome Measure

Overall survival (OS) [ Time Frame: Up to 5 years ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of MedicineBaltimoreMaryland21287-
Department of Radiation Oncology, Icahn School of Medicine at Mount SinaiNew YorkNew York10017-
Department of Radiation Oncology, Case Western Reserve UniversityClevelandOhio10900-
Division of Radiation Oncology, The Ohio State University WexnerColumbusOhio43201-

Find similar trials in Baltimore, MD

By condition
Head and neck cancer
By specialty
OncologyENT
By research site
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine· Baltimore, MDDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai· New York, NYDepartment of Radiation Oncology, Case Western Reserve University· Cleveland, OHDivision of Radiation Oncology, The Ohio State University Wexner· Columbus, OH

Related Studies