Patient Derived Preclinical Models

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT05324553
Status
Recruiting
Apply to this trial

Conditions

  • Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Tissue Collection — PROCEDURE
    Research tissue specimen will be obtained during the patient's clinical biopsy or clinical tumor resection, if feasible.
  • Blood Collection — DIAGNOSTIC_TEST
    Up to 50 mL of research blood will be drawn around the time of the procedure. Additional blood may be collected in selected cases, as warranted, to monitor disease recurrence/remission or perform additional
  • Buccal Swab — DIAGNOSTIC_TEST
    Buccal swab may be requested, if necessary, to generate germline data.

Study Details

Study goal is to collect tumor specimens that may inform cancer biology to eventually improve outcomes for patients with cancer. This proposal represents a highly collaborative effort to support cancer research with the goal of developing novel therapeutic strategies using patient derived preclinical models. This study is being done to collect samples of tumor tissues, matched normal tissue when possible, and approximately 50 mL of blood.

Key Dates

Start date
Apr 6, 2022
Status verified
Jun 2026
Primary completion
Mar 31, 2027
Completion
Mar 31, 2028

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Tissue Collection
    Research tissue specimen will be obtained during the patient's clinical biopsy or clinical tumor resection, if feasible.
  • Arm: Blood Collection
    Up to 50 mL of research blood will be drawn around the time of the procedure. Additional blood may be collected in selected cases, as warranted, to monitor disease recurrence/remission or perform additional testing
  • Arm: Buccal Swab
    Buccal swab may be requested, if necessary, to generate germline data.

Primary Outcome Measure

Number of participants accrued with genomic, microbiome, and drug sensitivity components of aggressive cancer. [ Time Frame: Up to 6 years post tissue and blood collection ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in RochesterRochesterMinnesota55905
Clinical Trials Referral Office
[email protected]
855-776-0015
Aaron S. Mansfield, M.D. (PRINCIPAL_INVESTIGATOR)

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