Sitting Interruption and Whole-body Cardiovascular Health

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT05316571
Status
Recruiting
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Conditions

  • Sedentary Behavior
  • Sedentary Time

Eligibility Criteria

Sex
ALL
Age
30 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • One 5-Minute Walking Bout Each Hour — BEHAVIORAL
    One 5-minute light intensity walking break per hour throughout the 4-hour SB condition
  • One 15-Minute Standing Bout Each Hour — BEHAVIORAL
    One 15-minute standing break per hour throughout the 4-hour SB condition
  • One 5-Minute Walking Bout and One 15-Minute Standing Bout Each Hour — BEHAVIORAL
    Two breaks per hour throughout the 4-hour SB condition, alternating between a 5-minute light intensity walking break and a 15-minute standing break
  • Uninterrupted Sitting — BEHAVIORAL
    No breaks will be provided throughout the 4-hour SB condition. This will be used as the control condition

Study Details

There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.

Key Dates

Start date
Aug 15, 2022
Status verified
Mar 2026
Primary completion
May 31, 2026
Completion
May 31, 2026

Study Design

Enrollment
56 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Active Comparator: One 5-Minute Walking Bout Each Hour
    A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary. The interruption strategy includes breaking up the 4-hour sitting bout with one 5-minute light intensity walking bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.
  • Active Comparator: One 15-Minute Standing Bout Each Hour
    A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary. The interruption strategy includes breaking up the 4-hour sitting bout with one 15-minute standing bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.
  • Active Comparator: One 5-Minute Walking Bout and One 15-Minute Standing Bout Each Hour
    A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary. The interruption strategy includes breaking up the 4-hour sitting bout with one 5-minute light intensity walking bout and one 15-minute standing bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.
  • Active Comparator: Uninterrupted Sitting
    A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary. This uninterrupted sedentary bout will serve as a control. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.

Primary Outcome Measure

Mean Change in Carotid-femoral Pulse Wave Velocity (cfPWV) [ Time Frame: Measurements will be taken immediately before and after each 4-hour SB condition ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of North Carolina at Chapel HillChapel HillNorth Carolina27599
Erik Hanson, PhD
[email protected]
919-962-0816
Erik D Hanson, PhD (PRINCIPAL_INVESTIGATOR)
Gaurav J Dave, DrPH (SUB_INVESTIGATOR)
Michelle Meyer, PhD (SUB_INVESTIGATOR)
Feng-Chang Lin, PhD (SUB_INVESTIGATOR)
Bethany Barone Gibbs, PhD (SUB_INVESTIGATOR)
Maihan Vu, DrPH (SUB_INVESTIGATOR)

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University of North Carolina at Chapel Hill· Chapel Hill, NC

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