Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

Part of paid clinical trials in Roanoke, Virginia.

Sponsor
Virginia Polytechnic Institute and State University
Study ID
NCT05303415
Status
Recruiting
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Conditions

  • Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Neuromodulation with low-intensity focused ultrasound — OTHER
    Application of LIFU to induce temporary neuromodulation, effects tested with resting state and heat evoked (QST) fMRI signals

Study Details

Study of LIFU on fMRI pain signals. Participants receive low-intensity focused ultrasound (LIFU) and fMRI scans to measure changes in both resting and heat pain signals. Physiology may also be measured. Questionnaires and symptom monitoring will take place. The study takes place over 4 study visits.

Key Dates

Start date
May 6, 2022
Status verified
Jun 2026
Primary completion
May 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
80 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: LIFU, heat evoked fMRI signals
    fMRI resting and heat evoked signals performed after LIFU application to known brain region of interest or active sham region (within participant all conditions tested).

Primary Outcome Measure

fMRI BOLD Signals [ Time Frame: Participant study duration, approximately 3 weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Fralin Biomedical Research InstituteRoanokeVirginia24016
Jessica Florig, MPH
[email protected]
5405262375

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By research site
Fralin Biomedical Research Institute· Roanoke, VA

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