Cannabidiol Effects on Learning and Anxiety

Part of paid clinical trials in Storrs, Connecticut.

Sponsor
University of Connecticut
Study ID
NCT05283382
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Anxiety and Fear

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Cannabidiol Oral Product — DRUG
    Participants will receive a one-time dose of 600 mg Cannabidiol Isolate Gel Capsules in the form of six 100mg capsules.
  • Placebo — OTHER
    Participants will receive a one-time dose of placebo capsules in the form of six capsules.

Study Details

To examine the extent to which Cannabidiol (CBD) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety. Undergraduates who display elevated social anxiety on standard assessments will be recruited at the University of Connecticut. All participants will be put in a standard fear conditioning paradigm where they are conditioned to fear a face that occasionally is followed by a shock to their wrist. The other face never is paired with a shock. After everybody learns this, half of the participants will receive 600 mg CBD Isolate Gel Capsules one time, and the other half will receive a placebo dose. Participants will then be presented with the faces with no shocks, and the rate and duration of extinction as measured by electrodermal response as well as subjective fear ratings via a visual analogue scale will be examined. It is hypothesized that participants that receive CBD will display enhanced extinction compared to the placebo group, as evidenced by reduced electrodermal response and reduced visual analogue fear ratings.

Key Dates

Start date
Oct 30, 2024
Status verified
Apr 2026
Primary completion
Dec 30, 2026
Completion
Feb 28, 2027

Study Design

Enrollment
160 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Cannabidiol
    600 mg Cannabidiol Isolate Gel Capsules / participant. One-time dose.
  • Placebo Comparator: Placebo
    Same number of placebo capsules / participant. One-time dose.

Primary Outcome Measure

Electrodermal activity [ Time Frame: 20 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of ConnecticutStorrsConnecticut06269-1020
Robert Astur
[email protected]
203-236-9938

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By research site
University of Connecticut· Storrs, CT

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