INTO-HLH: A Disease Registry for Patients With Hemophagocytic Lymphohistiocytosis (HLH)

Conditions

• Hemophagocytic Lymphohistiocytoses

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Not accepted

Study Details

The purpose of this observational study is to collect data on the natural history of disease of patients with Hemophagocytic Lymphohistiocytosis (HLH) including diagnosis, treatments, responses, and outcomes.

Key Dates

Start date

Dec 31, 2021

Status verified

Feb 2026

Primary completion

Jan 31, 2027

Completion

Jan 31, 2027

Study Design

Enrollment

200 participants (estimated)

Arms

• Arm: Patients with clinically suspected or confirmed Hemophagocytic Lymphohistiocytosis
  Multi-institutional cohort registry of patients with clinically suspected or confirmed Hemophagocytic Lymphohistiocytosis

Primary Outcome Measure

Time to HLH diagnosis from the initial presentation [ Time Frame: Interval between date of presentation, as defined as the day of appearance of initial HLH symptom, and the date of full HLH diagnosis, as defined by fulfilling the HLH diagnostic criteria, will be measured. Timeframes up to 6 months will be assessed. ]

Central Contacts

• Michael Jordan, MD
  (513) 803-9063
  [email protected]
• Adi Zoref Lorenz, MD
  [email protected]

Locations (1)

Find similar trials in Cincinnati, OH

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