TERPS Trial for de Novo Oligometastic Prostate Cancer

Part of paid clinical trials in La Jolla, California.

Sponsor
University of Maryland, Baltimore
Study ID
NCT05223803
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Prostate radiation (XRT) — RADIATION
    Both arms will receive prostate radiation. Multiple treatment regimens are allowed per protocol.
  • Systemic Therapy — DRUG
    All systemic therapy is provided as best prescribed for patient per their medical oncologist.
  • Stereotactic ablative radiation therapy (SABR) — RADIATION
    SABR is delivered to those randomized to Arm 2.

Study Details

This research is being done to see if we can improve the outcome of prostate cancer patients who present with metastatic lesions at initial diagnosis.

Key Dates

Start date
Oct 18, 2022
Status verified
May 2026
Primary completion
Jul 31, 2028
Completion
Jul 31, 2029

Study Design

Enrollment
122 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Best systemic therapy (BST) + primary prostate radiation (XRT)
  • Active Comparator: BST + XRT + SABR metastasis-directed therapy (MDT)

Primary Outcome Measure

To determine the 2-year failure-free survival (FFS) of men who have oligometastatic prostate cancer with BST+XRT versus BST+XRT+SABR MDT. [ Time Frame: 2 years ]

Central Contacts

Locations (10)

FacilityCityStateZIPSite coordinators
UC San Diego Moores Cancer CenterLa JollaCalifornia92093
Tyler Seibert, MD, PhD
[email protected]
858-822-6040
KU Medical Center- Cancer CenterKansas CityKansas66160
Xinglei Shen, MD
[email protected]
913-588-1227
Maryland Proton Treatment CenterBaltimoreMaryland21201
Nicole Helie
[email protected]
410-328-6304
UMMCBaltimoreMaryland21201
Nicole Helie
[email protected]
410-328-6304
Upper Chesapeake HealthBel AirMaryland21014
Lalicia Roman
[email protected]
443-643-1877
Central Maryland Radiation OncologyColumbiaMaryland21044
Caitlin Eggleston
[email protected]
410-328-7586
Baltimore Washington Medical CenterGlen BurnieMaryland21061
Pilar Strycula, RN, BSN
[email protected]
410-553-8110
Sidney Kimmel Cancer Center at Jefferson HealthPhiladelphiaPennsylvania19107
Jessie DiNome, MD
[email protected]
215-955-8874
UPMC Hillman Cancer CenterPittsburghPennsylvania15232
Adam Olson, MD
[email protected]
412-623-6720
Bon Secours Cancer Institute at St. FrancisMidlothianVirginia23114
Joseph Pennington, MD
[email protected]
804-266-7762

Find similar trials in La Jolla, CA

By condition
Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
UC San Diego Moores Cancer Center· La Jolla, CAKU Medical Center- Cancer Center· Kansas City, KSMaryland Proton Treatment Center· Baltimore, MDUMMC· Baltimore, MDUpper Chesapeake Health· Bel Air, MDCentral Maryland Radiation Oncology· Columbia, MD

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