Investigation of the Duration of Low-intensity Focused Ultrasound

Conditions

• Development of LIFU for Clinical Purposes

Eligibility Criteria

Sex

ALL

Age

18 Years - 65 Years

Healthy Volunteers

Accepted

Interventions

• Low-Intensity Focused Ultrasound — DEVICE
  LIFU application using various durations, responses of neuromodulation recorded using TMS and EMG.

Study Details

This project examines the effects of various durations of noninvasive neuromodulation on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, a functional Magnetic Resonance Image (fMRI) and computed tomography (CT). These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions of the hand.

Key Dates

Start date

Aug 26, 2022

Status verified

Jul 2025

Primary completion

Jun 30, 2026

Completion

Jun 30, 2026

Study Design

Enrollment

80 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Duration Trials
  Six different durations (three intermittent and three continuous) of LIFU application will be tested across six study sessions. Response recorded using TMS and EMG.

Primary Outcome Measure

Waveforms [ Time Frame: Outcomes assessed throughout participation - an average of 3 weeks. ]

Locations (1)

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