Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Cellular Therapy

Part of paid clinical trials in Omaha, Nebraska.

Sponsor: University of Nebraska
Study ID: NCT05135351
Status: Recruiting

Apply to this trial

Conditions

Eligibility Criteria

Sex: ALL
Age: 19 Years - N/A
Healthy Volunteers: Not accepted

Interventions

Resistant Starch — DIETARY_SUPPLEMENT
A prebiotic nutritional supplement available at commercial grocery and health food stores. Specifically, we will be using Bob's Red Mill® potato starch.
Maltodextrin — DIETARY_SUPPLEMENT
A starch commonly used as a placebo in prebiotic trials that is digested in the stomach and rapidly absorbed

Study Details

Higher gut microbiome diversity has been associated with improved survival following autologous stem cell transplantation in multiple myeloma and lymphoma. This study hypothesises that prebiotic supplementation with resistant starch (RS) will improve gut microbiome diversity at time of stem cell engraftment. To test this, participants will either have RS or a placebo (maltodextrin) mixed into a food item of their choice for approximately 10 days prior to stem cell infusion and continue to the first day of neutrophil engraftment. The study will look at the difference in gut microbiome diversity between the RS and placebo arm collected at the engraftment timepoint, dietary evaluation to assess the impact of subject diet on microbiome response to intervention and serum sample collection to assess differences to gut permeability during transplant.