Biomarker Profiling in Individuals at Risk for Prion Disease

Part of paid clinical trials in Charlestown, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT05124392
Status
Recruiting
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Conditions

  • CJD (Creutzfeldt Jakob Disease)
  • FFI
  • Familial Fatal Insomnia
  • GSS
  • Prion Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Study Details

We are doing this research to identify biomarkers in individuals who are at-risk for familial prion disease. We hope to use these biomarkers to predict timing of disease onset in pre-symptomatic individuals and to guide the direction of future clinical trials.

Key Dates

Start date
Dec 1, 2017
Status verified
Apr 2026
Primary completion
Jun 1, 2027
Completion
Jun 1, 2027

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Individuals with a family history of Prion disease
    Individuals with a family history of Prion disease

Primary Outcome Measure

CSF YKL40 [ Time Frame: 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Alzheimer's Clinical and Translational Research UnitCharlestownMassachusetts02129
Sophia D'Alessandro
[email protected]
617-726-4026
Alison McManus, DNP
[email protected]
6176434848
Steven E Arnold, MD (PRINCIPAL_INVESTIGATOR)

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