Testing the Contribution of Orbitofrontal Cortex Networks to Decision-making

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT05111223
Status
Recruiting
Apply to this trial

Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Real transcranial magnetic stimulation (TMS) before conditioning — DEVICE
    Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the conditioning phase of the task.
  • Real transcranial magnetic stimulation (TMS) before devaluation test — DEVICE
    Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the devaluation test phase of the task.
  • Sham transcranial magnetic stimulation (TMS) — DEVICE
    Sham TMS will be applied using the MagVenture MagPro X100 stimulator with the placebo side of the Cool-B65 A/P coil.

Study Details

This research study examines the contribution of orbitofrontal cortex (OFC) networks to decision-making.

Key Dates

Start date
Jul 12, 2022
Status verified
Aug 2024
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: TMS targeting OFC anterior networks
    Participants will receive TMS and sham targeting the OFC network.
  • Experimental: Experimental: TMS targeting posterior OFC networks
    Participants will receive TMS and sham targeting the posterior OFC network.

Primary Outcome Measure

Behavior on devaluation task [ Time Frame: 1 hour after intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Northwestern UniversityChicagoIllinois60657
Daria Porter, PhD
[email protected]
312-503-4223
Christina Zelano, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Northwestern University· Chicago, IL

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