The Effects of Dietary Supplementation on Serum Protein Glycosylation

Part of paid clinical trials in Sacramento, California.

Sponsor
University of California, Davis
Study ID
NCT05040204
Phase
PHASE1
Status
Recruiting
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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Monosaccharide Powder — DIETARY_SUPPLEMENT
    Monosaccharide powder dissolved in water.
  • Placebo Comparator — DIETARY_SUPPLEMENT
    Placebo (glucose powder)

Study Details

Two randomized double-blind placebo-controlled clinical studies to assess the effects of dietary glycan monomer supplementation on the immune system, especially antibody glycosylation in healthy adults. Immune profiling and glycoproteomics will be performed on serum isolated at these same time points.

Key Dates

Start date
Jun 23, 2022
Status verified
May 2026
Primary completion
Nov 22, 2026
Completion
Nov 22, 2026

Study Design

Enrollment
44 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Experimental Supplement 1
    6 subjects will consume 12 grams of dietary supplement 1 daily for 4 weeks
  • Experimental: Experimental Supplement 2
    6 subjects will consume 12 grams of dietary supplement 2 daily for 4 weeks
  • Experimental: Experimental Supplement 3
    20 subjects will consume 50 grams of dietary supplement 3 daily for 4 weeks
  • Placebo Comparator: Placebo Comparator 1
    6 subjects will consume 12 grams of placebo dietary supplement daily for 4 weeks
  • Placebo Comparator: Placebo Comparator 2
    6 subjects will consume 50 grams of placebo dietary supplement daily for 4 weeks

Primary Outcome Measure

Characterize Immunoglobulin fragment crystallization modifications [ Time Frame: 4 Weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Davis Medical CenterSacramentoCalifornia95816
Monica Tran, BS
[email protected]
916-551-2634
Emanual Maverakis, MD (PRINCIPAL_INVESTIGATOR)

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University of California, Davis Medical Center· Sacramento, CA

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