Alternation in the Human Microbiome With Commonly Used Topical Medications

Part of paid clinical trials in Sacramento, California.

Sponsor
University of California, Davis
Study ID
NCT03437005
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Desonide 0.05% — DRUG
    Desonide 0.05% ointment topically twice daily for two weeks
  • Ketoconazole 2% — DRUG
    Ketoconazole 2% cream topically twice daily for two weeks

Study Details

The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients. The specific aims are as follows: 1. Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use. 2. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.

Key Dates

Start date
Jan 28, 2013
Status verified
Feb 2026
Primary completion
Sep 28, 2026
Completion
Sep 28, 2026

Study Design

Enrollment
24 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Desonide 0.05%
    Low potency steroid topical medication applied to specific locations on the face and extremities, twice daily for two weeks
  • Experimental: Ketoconazole 2%
    Antifungal topical medication applied to specific locations on the face and extremities, twice daily for two weeks

Primary Outcome Measure

Number of bacteria per each species [ Time Frame: 2 weeks after initial dispensing ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Davis, Department of DermatologySacramentoCalifornia95816
Emanual Maverakis, MD
[email protected]
916-734-8254
Lauren Downing
[email protected]
916-551-2635

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By research site
University of California, Davis, Department of Dermatology· Sacramento, CA

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