Using Nicotine to Reverse Age-related Auditory Processing Deficits

Part of paid clinical trials in Irvine, California.

Sponsor
University of California, Irvine
Study ID
NCT04971954
Status
Recruiting
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Conditions

  • Aging
  • Auditory Perceptual Impairment

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Nicotine gum — OTHER
    Nicotine (6 mg) will be administered in the form of polacrilex gum that is available as an over-the-counter medication
  • Placebo gum — OTHER
    The placebo will also be a commercially available gum that resembles the nicotine gum in flavor, size, shape, color, and texture.

Study Details

The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.

Key Dates

Start date
Feb 1, 2022
Status verified
Mar 2026
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
48 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Nicotine gum
    Nicotine (6 mg) will be administered in the form of polacrilex gum that is available as an over-the-counter medication
  • Placebo Comparator: Placebo gum
    The placebo will also be a commercially available gum that resembles the nicotine gum in flavor, size, shape, color, and texture.

Primary Outcome Measure

Hearing thresholds [ Time Frame: 1 hour ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Hearing and Speech LabIrvineCalifornia92697
Fan-Gang Zeng
[email protected]
9498249107

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By research site
Hearing and Speech Lab· Irvine, CA

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