Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 2

Part of paid clinical trials in Richmond, Virginia.

Sponsor
Virginia Commonwealth University
Study ID
NCT04922762
Status
Recruiting
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Conditions

  • Peripheral Vascular Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Moderate Intensity, Normal Volume Exercise Training — BEHAVIORAL
    Week 1 3 days/week for 20 minutes/day Performed at 70% of heart rate maximum Week 2 3 days/week for 30 minutes/day Performed at 70% of heart rate maximum Weeks 3-10 3 days/week for 45 minutes/day Performed at 70% of heart rate maximum
  • High Intensity, Normal Volume Exercise Training — BEHAVIORAL
    Week 1 3 days/week for 31 minutes/day 10 minute warm up at 50% of heart rate maximum 2 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 7 minute cool down at 50% of heart rate maximum Week 2 3 days/week for 38 minutes/day 10 minute warm up at 50% of heart rate maximum 3 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 2 TIMES 7minute cool down at 50% of heart rate maximum Weeks 3-10 3 days/week for 45 minutes/day 10 minute warm up at 50% of heart rate maximum 4 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 3 TIMES 7 minute cool down at 50% of heart rate maximum
  • Moderate Intensity, High Volume Exercise Training — BEHAVIORAL
    Week 1 5 days/week for 20 minutes/day Performed at 70% of heart rate maximum Week 2 5 days/week for 30 minutes/day Performed at 70% of heart rate maximum Weeks 3-10 5 days/week for 45 minutes/day Performed at 70% of heart rate maximum

Study Details

The purpose of this research study is to examine the effect of various forms of exercise training on blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).

Key Dates

Start date
Dec 6, 2021
Status verified
Nov 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
360 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Moderate Intensity, Normal Volume Exercise Training
    Participants will complete study 1 (HM20020955-1) and then 10 weeks of moderate intensity, normal volume exercise training
  • Experimental: High Intensity, Normal Volume Exercise Training
    Participants will complete study 1 (HM20020955-1) and then 10 weeks of high intensity, normal volume exercise training
  • Experimental: Moderate Intensity, High Volume Exercise Training
    Participants will complete study 1 (HM20020955-1) and then 10 weeks of moderate intensity, high volume exercise training

Primary Outcome Measure

Arm Vascular Function at Rest (Flow Mediated Dilation Test) [ Time Frame: Baseline to the end of the final visit, about 14 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Virginia Commonwealth UniversityRichmondVirginia23298-

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By research site
Virginia Commonwealth University· Richmond, VA

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