Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1

Part of paid clinical trials in Richmond, Virginia.

Sponsor
Virginia Commonwealth University
Study ID
NCT04916327
Status
Recruiting
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Conditions

  • Peripheral Vascular Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Antioxidant — DIETARY_SUPPLEMENT
    Subjects will ingest an antioxidant cocktail containing 800 milligrams of alpha lipoic acid, 1 gram of vitamin C (ascorbic acid), and 400 milligrams of vitamin E (alpha tocopherol).
  • Placebo — DIETARY_SUPPLEMENT
    Subjects will ingest placebo (microcrystalline cellulose) pills.

Study Details

The purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).

Key Dates

Start date
Aug 23, 2021
Status verified
May 2026
Primary completion
May 31, 2026
Completion
May 31, 2026

Study Design

Enrollment
720 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Antioxidant then Placebo
    Subjects will ingest an antioxidant cocktail prior to their second visit and a placebo prior to third second visit
  • Experimental: Placebo then Antioxidant
    Subjects will ingest a placebo prior to their second visit and an antioxidant cocktail prior to their third visit.

Primary Outcome Measure

Arm Vascular Function at Rest (Flow Mediated Dilation Test) [ Time Frame: Baseline to the end of the final visit, about 2 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Virginia Commonwealth UniversityRichmondVirginia23298-

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By research site
Virginia Commonwealth University· Richmond, VA

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