Social Relationships and Accelerated Aging in Hematopoietic Cell Transplant Survivors

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
Medical College of Wisconsin
Study ID
NCT04892823
Status
Recruiting
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Conditions

  • Hematopoietic and Lymphoid Cell Neoplasm

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Biospecimen Collection — PROCEDURE
    Undergo collection of blood sample
  • Electronic Health Record Review — OTHER
    Review of medical records
  • Questionnaire Administration — OTHER
    Complete questionnaires

Study Details

This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.

Key Dates

Start date
May 18, 2021
Status verified
Jul 2025
Primary completion
May 31, 2026
Completion
May 31, 2026

Study Design

Enrollment
110 participants (estimated)

Arms

  • Arm: Supportive care (EAR, questionnaires, biospecimen collection)
    Participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.

Primary Outcome Measure

The number of participants with gene expression of cellular senescence marker p16. [ Time Frame: Day 100 and 1 year post-transplant ]

Central Contacts

  • Medical College of Wisconsin Cancer Center Clinical Trials Office
    866-680-0505
    [email protected]

Locations (1)

FacilityCityStateZIPSite coordinators
Froedtert Hospital and the Medical College of WisconsinMilwaukeeWisconsin53226
Kelly Rentscher, PhD
[email protected]
414-955-8990
Kelly Rentscher, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Froedtert Hospital and the Medical College of Wisconsin· Milwaukee, WI

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