Neural Correlates of Stress and Perceived Control in Adolescent Depression

Part of paid clinical trials in Belmont, Massachusetts.

Sponsor
Mclean Hospital
Study ID
NCT04788524
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
14 Years - 18 Years
Healthy Volunteers
Accepted

Interventions

  • Computer Task Manipulation — BEHAVIORAL
    Participants will complete computer tasks.

Study Details

Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.

Key Dates

Start date
Apr 23, 2021
Status verified
May 2026
Primary completion
Oct 31, 2026
Completion
Oct 31, 2026

Study Design

Enrollment
80 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Computer Task Manipulation
    Participants will complete computer tasks while undergoing an fMRI brain scan

Primary Outcome Measure

Blood-Oxygen-Level-Dependent Imaging (BOLD) activation of the ventral striatum and ventral medial prefrontal cortex [ Time Frame: 1.5 hour long scan during session 2 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
McLean HospitalBelmontMassachusetts02478
Emily L Belleau, PhD
[email protected]
617-855-4245
Emily L Belleau, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Belmont, MA

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
McLean Hospital· Belmont, MA

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