Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients

Part of paid clinical trials in Louisville, Kentucky.

Sponsor
Jiapeng Huang
Study ID
NCT04756076
Status
Recruiting
Apply to this trial

Conditions

  • Metal Poison
  • Pulmonary Hypertension

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Metal level measurements — DIAGNOSTIC_TEST
    Measure multiple metal levels

Study Details

Investigators plan to recruit 50 PAH patients from UofL PAH Clinic, with various degrees of severity (25 intermediate risk patients and 20 high risk patients) and 10 age and gender matched controls. PAH patients are evaluated at least every 6 months by the PAH Clinic and blood/urine samples will be obtained at each office visit. Blood, plasma and urine samples will be used to measure 31 metal levels including heavy metals (cadmium, arsenic, cobalt, lead etc.) and essential metals (calcium, copper, iron, zinc, potassium etc.) by the with ICP-MS via the service of ITEMFC. Interactions among the 31 metals in PAH patients, metal concentration differences between intermediate risk PAH, high risk PAH and control groups, the correlation between metal concentrations and the etiology, severity, duration, treatment, and progression of PAH/RV dysfunction over 12 months will be analyzed by CIEHS Biostatistics and Informatics Facility Core.

Key Dates

Start date
Dec 2, 2020
Status verified
May 2025
Primary completion
Dec 31, 2028
Completion
Dec 31, 2029

Study Design

Enrollment
110 participants (estimated)

Arms

  • Arm: Control
    age and gender matched controls
  • Arm: Pulmonary Hypertension Group
    Pulmonary Hypertension Patients with Various Degree of Severity

Primary Outcome Measure

Metal levels in control and pulmonary hypertension groups [ Time Frame: up to 12 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Louisville HealthLouisvilleKentucky40202
Jiapeng Huang, MD, PhD
[email protected]
5028528157
Jiapeng Huang, MD, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Louisville Health· Louisville, KY

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