Development of Liquid Biopsy Technologies for Noninvasive Cancer Diagnostics in Patients With Suspicious Thyroid Nodules or Thyroid Cancer

Conditions

• Thyroid Gland Carcinoma
• Thyroid Gland Nodule

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Biospecimen Collection — PROCEDURE
  Undergo collection of blood and tissue samples
• Electronic Health Record Review — OTHER
  Medical charts are reviewed

Study Details

This study is being done to help researchers learn more about and successfully diagnose cancer using blood samples and tissue samples from surgeries in patients with suspicious thyroid nodules or thyroid cancer. Diagnosing cancer in this way, as opposed to biopsies, may be less invasive to the patient. Analyzing blood and tissues samples may also help researchers to differentiate non-cancerous tumors from thyroid cancer and detect high-risk mutations to guide treatment.

Key Dates

Start date

Feb 21, 2020

Status verified

Mar 2026

Primary completion

Jun 9, 2025

Completion

Feb 1, 2027

Study Design

Enrollment

250 participants (estimated)

Arms

• Arm: Ancillary-correlative (biospecimen collection)
  Patients undergo collection of blood samples on the day of surgery following anesthesia but prior to incision and at the first routine blood test following surgery. Patients who undergo remnant ablation after total thyroidectomy with radioactive iodine have an additional blood sample collected. Patients also undergo collection of tissue samples following surgical resection of thyroid nodule or thyroid cancer. Patients' medical records are also reviewed.

Primary Outcome Measure

Sensitivity of molecular profile of thyroid-derived extracellular vesicles [ Time Frame: Up to 3 years ]

Locations (1)

Find similar trials in Los Angeles, CA

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