Early Life Stress and Depression: Molecular and Functional Imaging

Part of paid clinical trials in Belmont, Massachusetts.

Sponsor
Mclean Hospital
Study ID
NCT04713722
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
20 Years - 32 Years
Healthy Volunteers
Accepted

Study Details

Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experiences (they are resilient). In spite of this, little is known about the neurobiological mechanisms related to childhood adversity, especially oxidative stress abnormalities in the brain. To fill this gap, this study combines functional, structural, and molecular imaging approaches to examine the role of oxidative stress abnormalities related to childhood adversity.

Key Dates

Start date
Feb 1, 2021
Status verified
Dec 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: MDD/childhood adversity group
    subjects with current MDD who experienced childhood adversity
  • Arm: rMDD/ childhood adversity
    subjects with a history of MDD who experienced childhood adversity
  • Arm: MDD
    subjects in a current episode of MDD, with no history of childhood adversity
  • Arm: Healthy Control
    healthy control subjects, with no history of childhood adversity

Primary Outcome Measure

Immuno-oxidative abnormalities [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
McLean HospitalBelmontMassachusetts02478
David Crowley
[email protected]
617-855-4432
Diego Pizzagalli, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Belmont, MA

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
McLean Hospital· Belmont, MA

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