Acute Exercise and NK Cell Regulation in Tissue and Circulation After IL-6R Blockade

Sponsor
Rigshospitalet, Denmark
Study ID
NCT04616235
Status
Completed

Conditions

  • Appetitive Behavior
  • Interleukin-6 Inhibition
  • Physical Stress

Eligibility Criteria

Sex
MALE
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Tocilizumab Injectable Product — DRUG
    The intervention group will undergo intense aerobic exercise with prior IL-6R infusion for 1h prior to the exercise bout.
  • Saline 0.9% 100 ml NaCl 0.9% will be infused over 1 hour — OTHER
    The control group will undergo intense aerobic exercise with saline infusion for 1h prior to the exercise bout

Study Details

The study is a randomized controlled trial studying the acute effect of intense aerobic exercise upon NK (Natural Killer) cell activation and appetite-regulation in human participants with or without concommitant IL-6R receptor blockade (Tocilizumab)

Key Dates

Start date
Mar 15, 2021
Status verified
Aug 2022
Primary completion
Oct 4, 2021
Completion
Oct 4, 2021

Study Design

Enrollment
30 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: CON
    This group will do intense aerobic exercise without concomitant IL-6R blockade
  • Active Comparator: BLOCK
    This group will do intense aerobic exercise with concomitant IL-6R blockade

Primary Outcome Measure

Kinetics and regulation of NK (Natural Killer) cells during and following acute exercise [ Time Frame: Up to 1 day ]

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